diff --git a/spine-unity/Modules/com.esotericsoftware.spine.on-demand-loading/Editor/GenericOnDemandTextureLoaderInspector.cs b/spine-unity/Modules/com.esotericsoftware.spine.on-demand-loading/Editor/GenericOnDemandTextureLoaderInspector.cs
index f9168ce72..c5845ba72 100644
--- a/spine-unity/Modules/com.esotericsoftware.spine.on-demand-loading/Editor/GenericOnDemandTextureLoaderInspector.cs
+++ b/spine-unity/Modules/com.esotericsoftware.spine.on-demand-loading/Editor/GenericOnDemandTextureLoaderInspector.cs
@@ -206,13 +206,21 @@ namespace Spine.Unity.Editor {
 						Texture2D texture2D = AssetDatabase.LoadAssetAtPath<Texture2D>(texturePath);
 						if (texture2D) {
 							Color[] maxTextureSizePixels = texture2D.GetPixels();
-							texture2D.SetPixels(maxTextureSizePixels);
 
-							var bytes = texture2D.EncodeToPNG();
+							// SetPixels works only for non-compressed textures using certain formats.
+							var nonCompressedTexture =
+								new Texture2D(texture2D.width, texture2D.height, TextureFormat.RGBA32, false);
+
+							nonCompressedTexture.SetPixels(maxTextureSizePixels);
+
+							var bytes = nonCompressedTexture.EncodeToPNG();
 							string targetPath = Application.dataPath + "/../" + texturePath;
 							System.IO.File.WriteAllBytes(targetPath, bytes);
-							texture2D.Apply(updateMipmaps: true, makeNoLongerReadable: true);
-							EditorUtility.SetDirty(texture2D);
+
+							importer.isReadable = false;
+							importer.SaveAndReimport();
+
+							EditorUtility.SetDirty(nonCompressedTexture);
 							AssetDatabase.SaveAssets();
 						}
 					}